vendredi 8 février 2019
Posted by: Paola Pino
Role of bisphosphonates in alveolar ridge preservation
Bisphosphonates (BP) are often used to supress osteoclastic activity following tooth extraction. The effect of BP on extraction healing sites is largely unknown however. A recent study from Switzerland conducted an experiment to investigate the effect of BP on the healing of extraction sockets. They hypothesised that there would be a correlation between healing and the dosage of BP.
The study involved 15 male beagles. Three extraction sockets were treated with alendronate (ALDN), a form of BP, in concentrations of 0.5, 1 and 2mg/ml, followed by a saline rinse. An additional control extraction socket was rinsed with saline. Measurements of the buccal and lingual bone areas were taken at one, two and eight weeks.
Vertical distance between the buccal and lingual bone generally increased for the ALDN groups compared with the control. A significant difference was not observed between the three dosages. Across the various healing periods, bone mineral density across all groups remained similar.
From this study, the authors concluded that ALDN alone cannot prevent buccal bone resorption post-extraction in a canine model. It appeared that the formation of new bone within the socket benefited from ALDN treatment. Contrary to expectations however, no correlation was found between ALDN dosage and the healing of the socket.
This study was presented as an e-poster at the 2018 EAO Congress.